Journal: NPJ Biofilms and Microbiomes

Article Title: Statin therapy associated Lactobacillus intestinalis attenuates pancreatic fibrosis through remodeling intestinal homeostasis

doi: 10.1038/s41522-025-00695-w

Figure Lengend Snippet: a Comparison of lipid levels in the plasma between CP and control mice ( n = 6 per group). b Schematic illustration of experimental mouse models induced by high-fat diet (HFD), followed by caerulein injection. c Representative images of H&E staining, Trichrome staining, and IHC for Collagen-1 in SD-NC, SD-CP, HFD-NC, and HFD-CP groups. d Pathology scores, quantification of fibrotic area and Collagen-1 positive area in SD-NC, SD-CP, HFD-NC, and HFD-CP groups ( n = 8 per group). e Schematic illustration of CP mouse models, including PBS and atorvastatin (ATOR) treatment groups. f Western blot showing the expression of α-SMA in pancreatic tissues from NC, CP, and CP + ATOR mice, GAPDH was used as an endogenous control. g The quantification of α-SMA expression in pancreatic tissues (n = 3 per group). h Representative images of H&E staining, Trichrome staining, and IHC of α-SMA in NC, CP, and CP + ATOR groups. i Pathology scores, quantification of fibrotic area, and α-SMA positive area in each group ( n = 7 per group). j qRT-PCR detecting the expressions of α-SMA and fibronectin in CP tissues ( n = 5 per group), Gapdh was used as an endogenous control. Data are presented as mean ± SEM. ns, no significance; * p < 0.05; ** p < 0.01; *** p < 0.001. Figure ( b, e ) is from Figdraw 2.0 of HOME for Researchers (Permissions for use have already been obtained).

Article Snippet: For atorvastatin treatment, atorvastatin (MCE, Shanghai, China) or atorvastatin calcium tablet suspension (Pfizer, Shanghai, China) was given by oral gavage (10 mg/kg body weight) from two days after the first dose of caerulein injection.

Techniques: Comparison, Clinical Proteomics, Control, Injection, Staining, Western Blot, Expressing, Quantitative RT-PCR